Antiemetic Effects of Propofol After Laparoscopic Cholecystectomy

Abstract

We have studied the antiemetic effects of propofol after Laparoscopic cholecystectomy. One-hundred and fifty patients were allocated into three groups at random. Anesthesia was induced with thiopental 6mg•kg^-1 (Group T, n=50), propofol 3mg•kg^-1 (Group P1, n=50), and propofol 2mg•kg^-1 and 5mg•kg^-1•h^-1 was infused until the end of operation (Group P2, n=50). In all patients anesthesia was maintained with nitrous oxide in oxygen and epidural anesthesia. The rates of post operative nausea of Group T, P1 and P2 were 50, 32, and 40%, respectively. There were no significant differences among the three groups in the rate of vomiting and the frequency in the use of metoclopramide. Therefore, propofol did not reduce the incidence of post operative nausea and vomiting in patients undergoing Laparoscopic cholecystectomy.