Two Cases of Abortive Malignant Hyperthermia that Occurred during and after Tympanoplasty

Abstract

We experienced two cases of abortive malignant hyperthermia (a-MH) that occurred during tympanoplasty.
The two patients were young, muscular men, and they had no abnormal family history or past history of MH.
During the operation, a rise in body temperature was noted in the patients. After the operation, they complained of severe myalgia in their legs, and the creative kinase (CK) level on the day after the operation was abnormally elevated. Both patients were diagnosed as having a-MH.
Three weeks later, thigh muscle biopsy under local anesthesia was performed in both patients to examine the Ca²⁺ release function of the sarcoplasmic reticulum using skinned muscle fibers.
The findings of potentiated Ca²⁺-induced Ca²⁺ release from the sarcoplasmic reticulum when Ca²⁺ concentrations were 0 and 0.3μM suggested MH susceptibility.