1984 Volume 4 Issue 3 Pages 310-317
Under neuroleptic anesthesia maintained by continuous drip infusion of Ketamine, surgical patients with normal pulmonary function were washed in with constant concentrations of nitrogen (20 per cent), nitrous oxide (20 per cent) and halothane (0.5per cent) simultaneously by means of nonrebreathing artificial ventilator. The endtidal concentrations of each gases were measured by breath-by-breath manner. These data were analysed with nonlinear regression method from the simplest 2 compartment model.
Even this simplest model can show good curve-fitting to the measurements. The volume of distribution of nitrous oxide was 1.06-fold alveolar volume and that of halothane was 16.9-fold. The rate constant ratio of halothane to nitrous oxide was 7.22.
This method easily and immediately gives the proper model of each patient at the bed side. Anesthetists will obtain useful information about anesthetic pharmakokinetics of the patient on operating bed by the clinical application of that model.
