Abstract
A53years-old woman received the open heart surgery for the myxoma in left atrium under the cardiopulmonarybypass. After digoxin was administrated intravenouslly postoperativey in ICU, she suffered from chromopsia, nausea and vomiting which were suggestive of the digitalis intoxication. Plasma concentrations of digoxin were determined pharmacokineticaly with one compartment open model. The result of the anlysis calculated the high concentration of digoxin at the time when she started to complain the above symptoms and the digitalis intoxication was suspected. The usefulness of the therapeutic drug monitoring and the pharmacokinetic analysis of the drug were discussed in such a case.
