Evaluation of usefulness of midazolam for induction of anesthesia

studies on optimal dose in a modified NLA

Abstract

In order to estimate the optimal dose and adverse reactions when used simultaneously with laughing gas, pentazocine and muscle relaxant for induction and maintenance of anesthesia, midazolam was administered into 251 patients subject to surgical operation under general anesthesia. The patients were divided into 3 groups, one with the induction dose of 0.1mg, another with that of 0.2mg/kg and the other with that of 0.3mg/kg. The dose was increased for the maintenance of anesthesia by 0.1mg/kg 1.2 and 3 hours after the administration with the induction dose. As a result, it was proved that with the induction dose of 0.2mg/kg, anesthetic effects were satisfactory. Hypnotic effects were also good and no vascular pain or phlebitis were caused. Midazolam was considered to be very useful as a modified NLA.