Comparison of usefulness of midazolam with that of diazepam in a modified NLA

Abstract

A well-controlled comparative study was carried out with midazolam vs. diazepam in 234 patients subject to surgical operation on the usefulness for induction and maintenance of anesthesia in a modified NLA. One hour after injection i. m. with atropine sulfate and hydroxydine hydrochloride, 0.2mg/kg of midazolam or 0.2mg/kg of diazepam was administered i. v. to induce anesthesia, followed by the administration with 1mg/kg of pentazocine.
Midazolam was significantly superior to diazepam in the smoothness of induction of anesthesia, the depth of maintenance of anesthesia and in the grade of causation of vascular pain. There was no significant difference between the two drugs in the fluctuation of vital signs and the process after the operation in terms of arousal, start of spontaneous respiration and amnestic effects. No problematic adverse reactions were observed clinically or in clinical laboratory test results. Judging from the efficacy and safety, midazolam was considered to be more useful than diazepam in a modified NLA.