Abstract
Background : We report three rare cases of gliosarcoma (WHO/G4) with a poor prognosis.
Cases : Case 1 was a 60’s-year-old man, Case 2 a 70’s-year-old man, and Case 3 a 60’s-year-old woman. All had left temporal lobe tumors of varied size—7.5×4×4 cm in Case 1, 5×5×6 cm in Case 2, and 4×4×5 cm in Case 3—with cysts, found in magnetic resonance imaging (MRI). Crushed cellular images were all similar. Tissue sections were hard when crushed. Cellular, apparently strongly bound mesenchymal bundles were noted in samples. Cells and nuclei were markedly irregularly aligned. Large atypical varied-size cells irregular nuclear shapes appeared in a sparse binding pattern. All tissue images suggested tumors consisting of glioblastomatous cells and atypical spindle cells.
Conclusion : Glioblastomatous and spindle-cell components were difficult to differentiate. If the glioblastomatous component is considered to be loosened mesenchymal tissue, differentiation might be made between metastatic tumors and strongly atypical meningioma or neurinoma.
