Diagnostic criteria of the endometrial cytology based on the cytoarchitecture of tissue fragments

Abstract

Minimal pain to subjects makes cytological examination simpler and easier than histopathological examinations, but cellular atypia is poor in endometrial hyperplasia and well-differentiated endometrioid adenocarcinoma, limiting differential diagnosis of endometrial lesions based on cellular atypia.
Hormonal conditions and metaplastic changes adversely affect cytological findings when endometrial lesions change from benign to malignant, decreasing diagnostic utility.
We therefore regard diagnostic criteria setup in cell clump architecture reflecting histological architecture important in improving cytological diagnosis.