Abstract
Objective : To clarify the significance of human papillomavirus (HPV) test in squamous intraepithelial lesion (SIL), we carried out HPV test to women with SIL in uterine cervical cancer screening.
Study Design : We compared HPV test, coloposcopic biopsy and follow-up results in 190 women with LSIL, 76 women with HSIL suggested CIN2 and 69 women with HSIL suggested CIN3 diagnosed in uterine cervical cancer screening from April 2008 to March 2009.
Results : HPV test positivity was about 80% and showed no significant difference between LSIL, HSIL suggested CIN2 and HSIL suggested CIN3. Over CIN3 lesions were found 4.7% of LSIL, 32.9% of HSIL suggested CIN2 and 59.4% of HSIL suggested CIN3. HPV test showed no significant difference of detection rate over CIN3 lesion. HSIL suggested CIN2 with HPV negative showed significantly higher regression rate than those with HPV positive.
Conclusion : Among SIL, HPV test may be inadequate triage of coloposcopic biopsy for its high positivity. Colposcopic biopsy should be recommended in SIL. For high frequency of disappearance of atypical cells, long-range follow up may be interrupt in HSIL with both negative for HPV test or coloposcopic biopsy.
