Abstract
Objective : The aim of this study was to clarify the effectiveness of liquid based cytology and high-risk HPV testing for primary uterine cervical cancer screening.
Study Design : We compared the data on the number of unsatisfactory slides, number of work-up examinations needed and the rate of lesions more severe than CIN2 (CIN2+ rate) between 2006-2011, when only conventional cytology was used for mass screening, and 2012, when liquid based cytology and high-risk HPV testing were used in combination for the mass screening.
Results : The unsatisfactory slide rate was 0.042% during the period when conventional cytology was used and 0% during the period when liquid based cytology was used.
The number of work-up examinations and CIN2+ rate using liquid based cytology were 21 (1.8%) and 6 (0.5%) in town A, and 36 (2.3%) and 9 (0.6%) in village B, respectively in 2012, the rates being higher as compared to those in 2006-2011 when only conventional cytology was used.
We found 5 cases of ASC-US among the 95 slides subjected to high-risk HPV testing which were diagnosed as NILM in the first screening.
Conclusion : The CIN2+ rate increased with the use of liquid based cytology, because of the reduction in the rate of unsatisfactory slides.
Further examination is needed to determine the effectiveness of high-risk HPV testing.
