Abstract
Objective : We recently encountered several cases of low-grade squamous intraepithelial lesion (LSIL) with coexistent atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) cells, that were later diagnosed as cervical intraepithelial neoplasia (CIN) 2 or CIN3 by histopathological examination. Herein, we report the results of systematic comparison of the cytological and histopathological features of these cases.
Study Design : The materials were 444 cervical smears of LSIL, which were taken by the direct scraping method using a cytoblush between May 2009 and December 2010. The classification was done according to The Bethesda system 2001 including the category of LSIL-H (LSIL, cannot exclude HSIL).
Results : Among the subjects, 62 cases (14.0%) were reclassified into negative for intraepithelial lesion or malignancy (6 cases, 1.4%), ASC of undetermined significance (3, 0.7%), ASC-H (1, 0.2%), LSIL-H (31, 7.0%), and HSIL (21, 4.7%). Thus, 52 (83.9%) cases had high-grade lesions (LSIL-H and HSIL). Cervical biopsy was performed in 18 cases of LSIL-H. The histopathological diagnoses of the LSIL-H cases also included CIN2 (77.8%) and CIN3 (5.6%) in addition to CIN1 (11.1%) and benign lesions (5.6%).
Conclusions : These results suggest that we may need to consider the application of biopsy to LSIL cases with coexistent ASC-H cells (LSIL-H).
