Assessment of the adequacy of endometrial liquid-based cytology with the Beckton Dickinson SurePath^TM method

Abstract

Objective : The aim of this study was to assess the adequacy of endometrial liquid-based cytology using the Beckton Dickinson SurePath^TM method.
Study Design : A total of 1,097 endometrial samples were analyzed. The samples used for histological examination and cytological tests using conventional and SurePath^TM methods, were collected simultaneously.
Results : The sensitivity of the samples containing more than 10 cell clumps of more than 50 cells was significantly higher than those containing less than 10 cell clumps (78.7% vs. 36.8%). In contrast, as for the difference between clumps having more than 50 cells and having more than 30 cells, no significant difference was detected in the sensitivity, specificity, PPV, or NPV.
Conclusion : In the SurePath^TM specimens, the total number of clumps including small clumps is the most critical factor on which adequacy depends. Our study suggested that specimens containing more than 10 cell-clumps of more than 30 cells are adequate for examination with SurePath^TM.