2016 Volume 55 Issue 1 Pages 46-51
Background : Ovarian carcinosarcoma and neuroendocrine carcinoma are rare tumors. Moreover, coexistence of these two neoplasm is extremely rare.Herein, we report a case of ovarian tumor containing both carcinosarcoma and neuroendocrine carcinoma components.
Case : A 69-year-old woman presented to us with a history of abdominal pain. Computed tomography revealed a right ovarian tumor measuring 98×87×87 mm in size.Intraoperative ascitic fluid cytology showed atypical cell with an increased nuclear/cytoplasmic ratio were arranged in irregular and trabecular clusters. The cells showed diffusely positive staining for CD56 and synaptophysin, and focally positive staining for chromogranin A. No atypical cells were found in liquid based cytology of the cervix uteri or endometrium. These cytological findings were suggestive of neuroendocrine carcinoma of the ovary. Histopathological examination of the resected specimen revealed a diagnosis of carcinosarcoma with a neuroendocrine carcinoma component.
Conclusion : Ovarian neuroendocrine carcinoma has an extremely poor survival prognosis. Detection of high-grade neuroendocrine tumors by cytology may contribute to early decision on the treatment strategy.
