Cytological characteristics of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) in cancer institute hospital, with particular focus on age distribution

Abstract

Objective : The aim of this study was to clarify the cytological characteristics of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) in cancer institute hospital, with particular focus on age distribution.
Study Design : We examined ASC-H cases encountered during a 3-year period in our hospital. The results were compared to the histological diagnosis. The cytological findings of ASC-H were also evaluated according to the age distribution.
Results : 1) The ratio of ASC-H was 33.1%. 2) In the histologic diagnosis results, 46.2% of ASC-H cases were diagnosed as grade 2 cervical intraepithelial neoplasia or greater (CIN2+). The incidence of CIN3 was higher in the 60 s to 80 s age group compared to the 20 s to 50 s age group. 3) The Cytological characteristic of ASC-H in the 20 s to 50 s age group, resembled reserve cells or immature metaplasia cells, whereas in the 60 s to 80 s age group they resembled degenerated parabasal cells. 4) Crowding cluster with overlapping nuclei and mitosis were seen in 50.0% of carcinoma in situ and all of microinvasive squamous cell carcinoma cases.
Conclusion : There was a difference between the cytological characteristics of ASC-H in the 20 s to 50 s age group and the 60 s to 80 s age group. Characteristical findings were seen not to miss the high-grade squamous intraepithelial lesion (HSIL).