2019 Volume 58 Issue 6 Pages 266-271
Background : Follicular dendritic cell sarcoma (FDCS) is a neoplasm derived from the dendritic cells of lymphoid follicles. Because of its rarity, cytological diagnosis poses a challenge. We report a case of nodal FDCS, focusing on the cytological findings.
Case : A woman in her sixties was admitted to our hospital with a mass in the cervical region. Fine needle aspiration cytology showed clusters of loosely cohesive tumor cells with indistinct cell borders. The cytoplasm was abundant and foamy, and the nuclei were round to oval, with fine delicate chromatin, prominent nucleoli and delicate nuclear membranes. Initially, the findings were considered to be consistent with poorly differentiated carcinoma, and it was difficult to make further cytological diagnosis. Histologically, the resected tumor was found to be a tumor of the lymph node composed of proliferating epithelial-like cells arranged in a coalescent nodular pattern and spindle-shaped cells arranged in fascicles and whorls, admixed with small lymphocytes. In addition to these findings, the results of immuno-histochemical staining (CD21+) confirmed the diagnosis of FDCS.
Conclusion : The cytological findings in our case appeared to be characteristic and sufficiently useful to suggest the diagnosis of FDCS.
