2020 Volume 59 Issue 3 Pages 129-134
Objective : Primary cytologic screening has been regularly performed in Japan. In our clinic, a combination of cytology and a human papillomavirus (HPV) test (COM) has been performed since 2015. The primary HPV screening with cytological triage (pHPV) has been mainly done since 2017. We examined the distribution and frequency of abnormal cytology by both COM and pHPV during the last four years.
Study Design : Six hundred and sixty-nine patients comprised 404 cases with COM and 265 cases with pHPV, with 14 cases being excluded. Liquid-based cytology (SurePath) and an HPV test (cobas® 4800) were used for sampling.
Results : Between the COM and pHPV groups, the percentage of abnormal cytology of HPV positive cases among all 669 patients was almost similar, with 63.6% and 66.0%, respectively. The percentage of abnormal cytology was 78.6% with HPV positive cases in the pHPV group. On the other hand, 8.9% among the cases in the COM group with HPV negative in 458 cases were evaluated with both methods.
Conclusion : We concluded that pHPV would be an alternative to COM. Further studies are mandatory with a recall system for patients with no regular visit and both a post-screening algorithm and an accurate triage system is required for cases who show any discrepancy between the cytology and HPV test.
