Clinical Articles
A case of paraganglioma of the retroperitoneum with intranuclear cytoplasmic inclusions in the giant tumor cells
2020 Volume 59 Issue 3 Pages 147-151
Details
2020 Volume 59 Issue 3 Pages 147-151
Background : Paraganglioma is a rare tumor derived from the paraganglia, a neuroendocrine organ closely associated with the autonomic nervous system. Herein, we report a case of retroperitoneal paraganglioma with intranuclear cytoplasmic inclusions in the giant tumor cells.
Case : An 80-year-old woman was referred to our hospital because of an abdominal tumor detected by CT. Since a malignant lymphoma was suspected, a diagnostic excisional biopsy was performed.
Imprint cytology findings : The tumor cells were distributed singly or in loosely cohesive clusters, and showed anisokaryosis. Intranuclear cytoplasmic inclusions were also seen in some tumor cells.
Histopathological and immunohistochemical findings : The tumor cells showed a characteristic pattern of “Zellballen,” and positive staining for synaptophysin, chromogranin A, and CD56. Based on the findings, we diagnosed the tumor as a paraganglioma.
Conclusion : Paraganglioma is difficult to diagnose by cytology. We think that the presence of intranuclear cytoplasmic inclusions is one of the important markers to support the diagnosis of paraganglioma.
