2022 Volume 61 Issue 4 Pages 243-250
Objective : To objectively evaluate the diagnostic accuracy by standardizing the method of preparation of urinary cytology specimens, we compared the diagnostic accuracies of urinary cytology at our hospital obtained using various methods of preparation of the urinary cytology specimens.
Study Design : Samples from the past two years were compared and the diagnostic accuracies obtained using the wedge method (W method), cytospin method (CS method), the BD CytoRich method (CR method) for preparation of the specimens were compared. Specimens confirmed to be malignant by histological diagnosis were used to determine the sensitivity, while specimens confirmed to be benign by histological diagnosis and clinically negative specimens were used to determine the specificity ; based on “The 2015 Japan Reporting System for Urinary Cytology,” all urine samples were examined to analyze the risk of malignancy.
Results : The sensitivities obtained for the CS and CR methods were greater than 90%, higher than the sensitivity obtained for the W method (65%). The specificity for the CR method was lower than that for the CS method. When clinically negative specimens were included, a specificity of greater than 95% was obtained for all three methods of specimen preparation, with no significant differences. The risk of malignancy was less than 5% in the urine samples with negative cytology and greater than 80% in the urine samples showing malignant cytology.
Conclusion : The diagnostic accuracies of urine cytology obtained using the CS and CR methods for specimen preparation were higher than the diagnostic accuracy obtained for the W method. It is believed that objective evaluation of the diagnostic accuracy by standardizing the method of preparation of urinary cytology specimens, with strict operating procedures, will improve urinary cytology investigations.
