2023 Volume 62 Issue 1 Pages 1-9
Objective : To clarify the cell morphological differences among low-grade squamous intraepithelial lesion (LSIL)/cervical intraepithelial neoplasia (CIN) 1, high-grade squamous intraepithelial lesion (HSIL)/CIN2, and HSIL/CIN3.
Study Design : Among the patients who underwent cervical cytology between April 2013 and March 2016 and were diagnosed as having a LSIL or HSIL, we examined 42 patients with LSIL/CIN1, 37 with HSIL/CIN2, and 24 with HSIL/CIN3 in whom the diagnosis was confirmed by histological examination of biopsy material.
Results : The cytological findings of the specimens from patients with LSIL/CIN1, HSIL/CIN2 and HSIL/CIN3 are listed below. The appearance rates (numbers) of the parabasal type of atypical cells in LSIL/CIN1, HSIL/CIN2, and HSIL/CIN3 were 0.5% (9/1948), 2.9% (77/2671), and 49.7% (804/1619), respectively (p<0.01 for each). The optimal cutoff values of the number of parabasal type of atypical cells were LSIL/CIN1 vs. HSIL/CIN2 : 2.0, HSIL/CIN2 vs. HSIL/CIN3 : 9.0. The appearance rate of suspected squamous cell carcinoma cells, characteristically observed in patients with HSIL/CIN3, was 37.5% (p<0.01 for each).
Conclusion : In this study, we estimated the number of parabasal type of atypical cells and the appearance rate of suspected squamous cell carcinoma cells.
