2025 Volume 64 Issue 4 Pages 175-181
Objective : To examine individual histological results and their changes over time in cases with cervical cytology results of “atypical squamous cells, cannot exclude HSIL (ASC-H)” at our facility.
Study Design : The subjects were 47 patients from our facility who underwent cervical cytology and cervical biopsy on the same day (same-day biopsy) with the cytological results categorized as ASC-H ; we investigated the histological results in all of these patients ; histological results of the same-day biopsy → highest diagnosis during the course (highest diagnosis) → final diagnosis. We also examined the histological results with reference to the three types of atypical cells used to diagnose ASC-H : immature metaplastic cell atypia (IM-atypia), intermediate-to-parabasal squamous cell atypia (IPS-atypia), and atrophic squamous cell atypia (AS-atypia).
Results : Of the 47 cases, histology revealed CIN2 or higher (CIN2＋) on the same-day biopsy in 25 (53.2％) cases → as the highest diagnosis in 40 (85.1％) cases → as the final diagnosis in 32 (68.1％) cases. The corresponding percentages of CIN2＋ were 14.3％ → 71.4％ → 42.9％ in the group with IM-atypia, 65.4％ → 92.3％ → 76.9％ in the group with IPS-atypia, and 85.7％ → 85.7％ → 85.7％ in the group with AS-atypia.
Conclusion : These results suggest that in the ASC-H cases examined in this study, the subsequent course and prognosis varied depending on the type of atypical cells on which the diagnosis of ASC-H was based on.
