2025 Volume 64 Issue 4 Pages 200-203
A man in his 60 s presented with a slow-growing cystic mass in the right submandibular gland. Cytological examination of the fluid aspirated from the cyst revealed scattered papillary cell clusters. The cytoplasm was lacy and partially vacuolated, and contained irregularly shaped, unevenly distributed nuclei with prominent nucleoli. A possible diagnosis of adenocarcinoma was made and the tumor was resected. Histological analysis confirmed the diagnosis of submandibular gland cystadenocarcinoma, which can be cytologically differentiated from lateral cervical cyst, Warthin’s tumor, mucoepidermoid carcinoma, and cystadenoma of the salivary gland, but is difficult to differentiate from secretory carcinoma and intraductal carcinoma.
