Abstract
The cytologic features of 49 cases with dyspla sia, carcinoma in situ and early invasive carcinoma of the uterine cervix were precisely examined in correlation with histopathologic findings.
1. The histologic diagnsis of biopsy specimen was not always the same with final diagnosis based on the serial or step section of conization or resec ted uterus.
2. In general the narrower area of atypical epithelium, as determined by serial sections, were associated with fewer atypical cells in cellular samples while with the wider area of lesions the abnormal cell count was higher.And also the area of atypical epithelium in dysplasia was usually narrower than those in carcinoma in situ or invasive cancer.
3. In order of dysplasia, carcinoma in situ and invasive cancer mean nuclear diameter and mean cell diameter less and less reduced in size and nuclear cytoplasmic ratio increased more and more.
4.As for the chromatin pattern, nuclear membrane and cell configuration cellular samples from dysplasia showed rather different characteristics than samples from carcinoma in situ and invasive cancer. But there was no deffinite difference between the last two entities.
5.Though the cytologic specimens from dysplasia, carcinoma in situ and invasive cancer have each characteristic feature in general, it must bekept in mind that there remain certain indistingui shable cases.
6.The cytologic features in carcinoma in situ and invasive cancer are occasionally affected by the coexisting dysplasia. The consideration to such coexisting lesion must be important in diagnostic cytology of these borderline lesions.
