Abstract
It has been noted in recent years that abnormal cells suggestive of malignancy occasionally appear after artificial abortion. Examination of these abnormal cells by dividing them into the decidual type, cylindrical epithelium type, and miscellaneous type, revealed that the decidual type appears mainly within 2 weeks after abortion, while most of the cylindrical epithelium type appear thereafter.
In order to elucidate the character and origin of these abnormal cells, studies have been conducted from a viewpoint of cellular nuclear DNA by performing cell analysis, using aspirated endometrial cells and re-curettage materials after abortion, in order to determine the nuclear DNA patterns with ICP, a kind of FCM. As a result, two groups, Group A having a peak in only the diploid area, and Group B having a very low peak in the triploid and tetraploid areas, were distinguishable.
Group A is observed mainly within 10 days, while most of Group B is noted after 20 days onwards. Consideration of this fact, together with the observed pattern of appearance of cells, led the author to believe that the low peak in the polyploid areas observed in Group B corresponds to newly generated cells with a brisk rate of division among the cylindrical epithelial cells. On the other hand, the abnormal decidual cells are considered to be decidual cells which have degenerated after abortion, from the fact that their DNA mode shows the normal diploid pattern.
