Abstract
A case of pleomorphic liposarcoma mimicking malignant fibrous histiocytoma by means of needle aspiration cytology were reported.
The characteristic cytological findings were as follows:
1) Tumor cells were arranged in small and large clusters, occasionally storiform like pattern were found.
2) The cytoplasma appeared foamy with multiple small vesicles, and a few of signet-ring cell type were seen here and there.
3) The nuclei of tumor cells were elliptical and irregular in shape, varied 7-35 micron in size, and were composed of severe increased chromatin with fine granular pattern. As nuclear size enlarged, irregularity of nuclear margin was prominent.
4) Some moderate sized tumor cells had a small nucleoli and bizzar giant cells with 2-5 nuclei were seen. This aspiration cytology suggested malignant fibrous histiocytoma. The well-marginal tumor removed surgically, located at the superficial fatty tissue of the buttocks, was 3×2.5 cm and the cut surface was whiteyellow in color, in part bleeding was seen. Histologically, there was much difficulty to distinguish liposarcoma from malignant fibrous histiocytoma. At the electron microscopic level, this tumor consisted of mononuclear and multinuclear giant cells with a few and/or many lipid droplets. The electron microscopic findings were obviously different from those of malignant fibrous histiocytoma.
Finally, we diagnosed pleomorphic liposarcoma.
