Abstract
Distributions of nuclear DNA content in 40 cases of human gastric cancer were assessed by microspectrophotometry of Feulgen-stained imprints and the relationship to the histologic types was evaluated. Although correlation was not clearcut, there was a tendency that well differentiated adenocarcinomas exhibit a bimodal DNA histogram pattern and poorly differentiated adenocarcinomas demonstrate a very broad DNA distribution with or without a distinct peak. Cellular DNA content was in a linear relationship to nuclear size, and it seemed possible to grossly estimate the variability of DNA content by eye on an usual cytology preparation. DNA histogram of signet-ring cell carcinomas was rather characteristic and showed a high peak of narrow width which was composed of typical signet-ring cells, suggesting that the cells are Go population.
