Malignant histiocytosis which appeared in the pleural effusion and ascites

Abstract

A case of a female with pleural effusion and ascites without typical initial manifestations of malignant histiocytosis, who died on the 30th hospital day, is presented.
In the fluids of these cavities, many undifferentiated cells and variously differentiated abnormal histiocytes which showed erythrophagocytosis, and multinucleated cells were observed. They showed marked nuclear atypism. Diffuse infiltration of atypical histiocytes was also confi rmed in various organs and tissues, especially lymphnodes and omentum after postmortem examination. From the cytological and histopathological aspects, this case was diagnosed to be an atypical malignant histiocytosis.