1984 Volume 23 Issue 1 Pages 77-83
A case of mixed mesodermal tumor of the uterine corpus confined to the endometrium was presented. The patient was 52 year-old, gravida 0, para 0, woman who complained atypical genital bleeding and lumbar pain.
In the vaginal pool smear, clusters of adenocarcinomatous cells were obserbed, and we suspected endometrial carcinoma. Abdominal hysterectomy was performed, macroscopically a 3×2.5×2.5 cm sized, dark red colored, pedunculated polypoid tumor was obserbed at the posterior wall of the endometrium near the fundus. Microscopically, the tumor was composed of carcinomatous and sarcomatous elements. The former was well differentiated adenocarcinoma. The latter were composed of leiomyosarcoma and endometrial stromal sarcoma (as homologous elements), and rhabdomyosarcoma and myxomatous myxomatous tissue (as heterologous elements). Immature rhabdomyblasts were obserbed in rhabdomyosarcoma but we failed to demonstrate cross striations by PTAH stain. Diastase resistant PAS staining was positive in these cells.
We reexamined the vaginal pool smear and detected only one unusual multinucleated giant cell which was thought to be derived from the sarcomatous tissue. So, we considered that we may be able to diagnose carcinosarcoma or mesodermal mixed tumor by the recognition of a biphasic cellular pattern consisting of carcinomatous cells and sarcomactous cells.
Mesodermal mixed tumor of the uterus has been considered to be fatal, but when it is confined to the uterus especially to the endometrium, it's prognosis may be good by sugery alone.
