1986 Volume 25 Issue 4 Pages 758-763
A case of granular cell tumor of the breast has been studied by cytology, histology and electron-microscopy. In cytological samples, granular cells with coarsely granular, ill defined cytoplasm were seen in clusters or in single. Angulated body cells with angular inclusion bodies were seen around or in the clusters of the granular cells. These inclusion bodies were unstained and slightly birefringent by Papanicoloau stain, pale blue by Giemsa stain and strongly PAS positive. Histologically, granular cells with weakly eosinophilic and coarsely granular cytoplasm were lobulated in cell nests by fine fibrovascular tissue. Spindle cells with strongly PAS-positive and angulated inclusion bodies (angulated body cells) were seen in thefibrovascular stromal tissue. By electron-microscopy, angulated body cells looked-like fibroblasts contained eliptical or round inclusion bodies. These inclusion bodies were composed of parallel stacks of filaments or segmented bimolecular structures.
In the cytological and histological diagnosis of granular cell tumor, it is an important criterion to identify the angulated body cells in addition to the granular cells.
