1987 Volume 26 Issue 1 Pages 134-140
Cytological observations were made on the morphological changes and number of tumor cells, as well as on rational changes of mesothelial cells, lymphocytes, histiocytes and neutrophils, following chemotherapy using cisplatin and other anticancer drugs in combination in four advanced cases of ovarian cancer and a case of endometrial cancer associated with ascites. These five cases were studied, and the results were as follows:
1) An decrease in the number of malignant cells was observed in the cases in which chemotherapy was effective.
2) Nuclear enlargement, cell enlargement, cytoplasmic vacuolation, partial aggregation of chromatin and disappearance of mitotic cells were prominantly observed in the cases in which chemotherapy was effective.
3) The ratio of mesothelial cells deceased markedly in the effectively treated cases. In contrast, the ratio of lymphocytes was increased or less decressed in the effectively treated cases.
