1987 Volume 26 Issue 1 Pages 7-14
In the present study, the cytological examination was performed on cervical human papillomavirus (HPV) infection with no dysplasia during the follow-up period. The subjects enrolled in this study were 6 cases in total including 1 case followed up for 5 years and 5 cases followed up for 1.6-3.0 years.
1) In the diagnostic cytology, the evidences which have been established so far concerning the cytology of cervical HPV infection could be applied to the cytological follow-up for a long term period. Koilocytes did not always appear upon every observation time, dyskeratocytes appeared frequently. Binucleation, amphophilic cells, giant cells and eosinophilic background were observed only sporadically case by case.
2) Some identifiable findings which were observed in individual cases throughout the follow-up course attracted our attention in this study, that is, the appearance of metaplastic cells accompanied with inmature cells in 4 cases, the appearance of koilocytes in 1 case and giant cells and binucleation in 1 case.
3) In one case of warty atypia the course of which could be followed up for 5 years, less findings suggestive of HPV infection were obtained cytologically as well as histologically but only colposcopy revealed the presence of this disease in the beginning of the follow-up period. However, only cytology indicated this disease with no or weak evidence by colposcopy or histology in the latter stage. It is thus considered that the follow-up diagnosis of cervical HPV infection must be performed cooperatively by mean of colposcopy, cytology and histology.
