Abstract
In the present study, cytological examination was performed in 3 cases of cervical papillomavirus (HPV) infection with CIS during the follow-up period.
For comparison, 4 cases of HPV infection with severe dysplasia were observed simultaneously.
1) CIS complicated cases: The age of patients with CIS complicated cervical HPV infection ranged from 42 to 46 years old averaged 44 years old, and the observation was continued for 4 months at shortest to 2 years and 2 months at longest, averaged 1 year and 4 months. After the diagnosis of moderate to severe dysplasia had been established by histological examination, CIS was diagnosed within 4 months at shortest to 1 year and 8 months at longest, 11 months on the average, by histological examination.
Severe dysplasia complicated cases: The age of these patients ranged from 36 to 38 years, averaged 37.3 years old, and the duration elapsed from mild to severe dysplasia was 4 months to 2 years and 3 months, averaged 1 year and 5 months.
2) Koilocytes appeared inconstantly, while dyskeratocyte appeared constantly during the follow-up course. There was no invariable finding during the observation period with regards to amphophilia eosinophilic background, binucleation and giant cell.
3) In CIS complicated cases, relatively identifiable findings which characteristically and frequently appeared in patients with HPV infection alone or those with mild dysplasia complicated HPV infection were no longer observed distinctly. Nuclear atypism (morphological change of nuclei to malignancy) was extremely remarkable, indicating that some signifi cant and intrincical change must have occurred in such cells as bearing cervical HPV infection. Nuclear atypism was observed mainly in those cells of intermediate type, parabasal type or immature metaplastic type.
