1995 Volume 34 Issue 4 Pages 646-650
A case of Adenoma Malignum is reported, with microscopical findings, histopathological stereo-structural findings and the measurement of DNA content. The patient was a 68 year-old married woman. Cytologic examination of the uterine cervical scratch smear showed several clusters in a sheet, with an acinus and a palisade consisting of high columnar epithelial tumor cells containing round nuclei, prominent nucleoli and fine granular or fine reticular chromatin. Histological study revealed the proliferation of cervical columnar epthelial tumor cells with marked mucous production and invasion into the deep muscular layer with papillary growth and the irregular projection of glandular ducts. With the result of stereo-structural study of the neoplastic duct, extraordinary dilatations, irregular bifurcations and lateral projections of glandular ducts were recognized. It was suggested that these findings were consistent with clusters of sheet like or acinus cells in cytology. Comparson of normal cervical glands with neoplastic glandular ducts in the stereo-structural study, suggested the usefulness of this method for distinguishing adenocarcinoma in situ from microinvasive adenocarcinoma regardless of whether or not. acinus cell clusters are presented. The measurement of DNA content showed a diploidy pattern with 2.2C at the peak.
