Abstract
We report a case of neuroendocrine small cell carcinoma of the uterine cervix suspected from cytology and biopsy. We detected a cervical mass 3 cm in diameter in a 33-year-old female who had contact bleeding. Radical hysterectomy was performed, followed by chemotherapy (cisplatin, doxorubicin and etoposide) and whole pelvic irradiation.
Preoperative smear cytology of the cervix showed small uniform tumor cells with scant cytoplasm and a high nuclear/ cytoplasm ratio. The nuclear chromatin showed a coarsely granular pattern and the nucleoli were inconspicious.
Histology of the surgical specimen showed predominantly small cells arranged in solid nests with rosette-like structures and 15 mitoses in 10 high power fields. The tumor cells were Grimelius stain-positive and Masson-Fontana stainnegative. Immunohistchemically, neuron-specific enolase and chromogranin A were positive. The electronmicroscopic diagnosis was neuroendocrine small cell carcinoma with neurosecretory granules.
