Abstract
Objective: The incidence of endometrial carcinoma in Japan is increasing. Endometrial hyperplasia is thought to be a precancerous lesion of endometrial carcinoma due to the following reasons.(1) The hyperplasia progresses to endometrial carcinoma after long-term follow-up, (2) in the cases with endometrial carcinoma which progressed from endometrial hyperplasia the hyperplasia oxccupies a large area of the endometrium and (3) endometrial hyperplasia often coexists with early endometrial cancer. According to these findings, close examination of endometrial hyperplasia might be expected to reveal early stage endometrial carcinoma. Endometrial hyperplasia is classified into 4 groups based on the presence or absence of cytologic atypia and architectural complexity (General rules for clinical and pathological management of uterine corpus cancer, 1996); simple hyperplasia, complex hyperplasia, simple atypical hyperplasia and complex atypical hyperplasia.
Conclusion: Our cytological findings of complex hyperplasia were;(1) 1 the back ground is not usually necrotic, but is bloody, (2) cellular clusters of normal-looking cells appear more often in hyperplasia than normal proliferative endometrial phase, (3) papillary or peninsula-like structures protruding from the periphery of cellular clusters are observed, (5) back to back structures and stratification in the clusters are seen, and (6) the palisading pattern of the border of clusters appears irrgular. In cases of complex atypical hyperplasia, additional findings are prominent stratification of cellular clusters and marked anisonucleosis and prominent nucleoli.
