Correlation of cytological findings with human papillomavirus (HPV) type

Abstract

Objective: To investigate cytological findings that correlated with human papillomavirus (HPV) type.
Study design: We investigated 82 cytological specimens from uterine cervix of human papilloma virus (HPV) infection with PCR-RELP. Furthermore we analyzed the relationship among HPV type, histological diagnosis and cytological findings.
Results: 1) Significantly more cases of histological malignancy were pocitive for the HPV genome. 2) On cytology, the appearance of immature metaplastic cells was associated with HPV 16 and correlated with histological malignancy. Parakeratosis was associated with HPV 52. Orangeophilia was correlated with histological malignancy. 3) When we adopted it positive finding for HPV 16 infection immature metaplastic cells appeared more than 10.0 %o of total cells, we achieved a diagnostic sensitivity of 75.0% and a specificity of 92.7%.Conclusion: The appearance of immature metaplastic cells is a feasible marker for screening for HPV 16 infection.