1999 Volume 38 Issue 6 Pages 621-622
Prostatic duct adenocarcinoma (PDC) is a rare variant of prostatic cancer which simulates uterine endometrioid adenocarcinoma on histology.
A 77-year-old male presented with gross hematuria. Cystoscopically, there was an exophytic lesion protruding into the prostatic urethra at the verumontanum. Voided urine cytology showed irregular-sized numerous aggregations of small epithelial cells with columnar features. They had small, hyperchromatic, round to oval nuclei arranged in a palisading pattern with inconspicuous nucleoli and varying amounts of cytoplasm. Immunocytochemically, the tumor cells were positive for prostate specific antigen (PSA).
Differentiation between PDC and transitional cell carcinoma depends on identification of columunar features and immunocytochemical staining for PSA.
