Abstract
Objective: The aim of this study was to clarify the characteristics of extrauterine adenocarcinoma cells detected in endometrial cytology from cases with or without endometrial metastasis.
Study Design: Endometrial cytology as well as VCE smears were reviewed from 37 cases with extrauterine adenocarcinoma (10 cases of breast cancer, 9 of ovarian cancer, 6 of gastric cancer, 3 of fallopian tube carcinoma, 3 of rectal cancer, 3 of colon cancer, 2 of pancreatic cancer and 1 of gallbladder carcinoma). Pathological review of endometrial biopsy and/or operation materials from all cases revealed that 13 out of 37 (35.1%) cases had endometrial histological metastasis.
Results: None of the cases without endometrial metastasis had tumor diathesis, while 30.8% of cases with endometrial metastasis had tumor diathesis. Cancer cells were detected in VCE smears from 76.9% and 26.1% of cases, with and without endometrial metastasis, respectively. Cell clusters from most cases with endometrial metastasis showed “getting-loose” findings around the edge of clusters.
Conclusions: These results suggest that cases with endometrial metastasis can be distinguished from those without based on the findings of tumor diathesis and the characteristic features of cell clusters in endometrial cytology.
