Abstract
Objective: To increase the accuracy of endometrial cytology, we evaluated the use of architectural atypia as a possible diagnostic criterion and the use of cell culture medium to decrease the frequency of insufficient materials.
Study Design: We selected 84 cytologically suspicious cases for which histological diagnoses were available, dividing them into 2 groups-51 in group A diagnosed with cellular atypia, and 33 in group B with architectural atypia and an additional washing smear.
Results: Histological findings of group A cases showed 23 (45.1%) that were benign, 21 (41.2%) with endometrial hyperplasia, and 7 (13.7%) with endometrioid adenocarcinoma, grade 1. In group B, 11 (33.3%) cases were benign, 21 (63.7%) were endometrial hyperplasia, and 1 (3.0%) was endometrioid adenocarcinoma, grade 1. The percentage of cases with insufficient material for diagnosis was 32.9% in group A and 20.0% in group B.
Conclusion: Focusing on architectural atypia effectively raises the accuracy of endometrial cytological diagnosis for endometrial hyperplasia. The additional washing smear was useful in endometrial cytology.
