Abstract
Cytology progressed dramatically in the 20th century, and has matured beyond being an ancillary diagnostic method. Even so-called “borderline” lesions in some organs can be diagnosed by cytology alone. The definition of borderline lesions is fuzzy, however, especially for “precancerous” lesions. In some other organs, borderline lesions are difficult to diagnose by cytology alone.
The concept and problems with borderline lesions must be clearly defined and a consensus reached on criteria for cytological diagnosis.
Borderline and precancerous lesions should be clarified using imaging, immunocytochemistry, DNA ploidy analysis, and molecular biology. I hope this proposal will be accepted in the near future.
