Clinical significance of cytology of chorionic villi in spontaneous recurrent abortion

Abstract

Objective: We studied the clinical significance of cytology of chorionic villi in recurrent spontaneous abortion.
Study Design: We analyzed histological and cytological findings in chorionic villi in recurrent spontaneous abortion, using chorionic villi specimens from episodic abortion in fertile cases as the control.
Results: The incidence of apoptosis and infiltration of mononu-clear cells in recurrent spontaneous abortion increased both histology but also cytologically. No marked difference was observed in villous structure in either group.
Conclusion: Histological and cytological findings in recurrent spontaneous abortion are similar to allograftic reaction. We surmise that many cases are related to immune reaction. Cytology studies of chorionic villi could thus contribute to the early diagnosis of etiology and early treatment of recurrent spontaneous abortion.