2005 Volume 44 Issue 4 Pages 245-249
Background: No previous reports have, to our knowledge, described the urine cytology of urinary bladder sarcomatoid carcinoma.
Cases: Case 1: A 4cm nodular lesion found in the urinary bladder of a 59-year-old woman showed larger high-grade atypical cells characterized by a thick nuclear rim, constricted nuclei, or multinuclei in urine cytology. Histologically, scattered foci consisting of highgrade malignant epithelial cells were found in sarcomatoid lesions.
Case 2: A nodular tumor accompanied by small G2 papillary urothelial carcinomas was observed in the urinary bladder of an 87-year-old woman the fourth recurrence. Urine cytology showed papillary-like cell clusters consisting of middle-sized atypical urothelial cells and other more atypical cells, i. e., irregular cells sized from small to large, round cells with round and irregular-shaped nuclei having increased chromatin, and spindle cells with nuclei situated at cell center. Histologically, the tumor consisted of atypical spindle cells that produced many foci of cartilage and bone tissue.
Conclusion: When strangely shaped atypical cells in addition to ordinary urothelial cancer cells are found during the daily urine cytology, sarcomatoid carcinoma should be posed as a possible diagnosis.
