分葉状頸管腺過形成 (LEGH) と悪性腺腫の細胞学的・組織学的検討

端 晶彦; 弓納持 勉; 村田 晋一; 近藤 哲夫; 奈良 政敏; 中澤 久美子; 端 圭子; 大森 真紀子; 加藤 良平; 星 和彦

doi:10.5795/jjscc.45.126

Cytological and histological study on lobular endocervical glandular hyperplasia and minimal deviation adenocarcinoma of the uterine cervix

Akihiko HASHI, Tsutomu YUMINAMOCHI, Shinichi MURATA, Tetsuo KONDO, Masatoshi NARA, Kumiko NAKAZAWA, Keiko HASHI, Makiko OMORI, Ryohei KATOH, Kazuhiko HOSHI

Author information

Akihiko HASHI
Department of Obstetrics and Gynecology, University of Yamanashi
Tsutomu YUMINAMOCHI
Clinical Laboratory, University of Yamanashi
Shinichi MURATA
Department of Pathology, University of Yamanashi
Tetsuo KONDO
Department of Pathology, University of Yamanashi
Masatoshi NARA
Department of Obstetrics and Gynecology, University of Yamanashi
Kumiko NAKAZAWA
Clinical Laboratory, University of Yamanashi
Keiko HASHI
Department of Obstetrics and Gynecology, University of Yamanashi
Makiko OMORI
Department of Obstetrics and Gynecology, University of Yamanashi
Ryohei KATOH
Department of Pathology, University of Yamanashi
Kazuhiko HOSHI
Department of Obstetrics and Gynecology, University of Yamanashi

Keywords: Lobular endocervical glandular hyperplasia (LEGH), Minimal deviation adenocarcinoma (MDA), Intranuclear cytoplasmic inclusion (INCI), Cytology

JOURNAL FREE ACCESS

2006 Volume 45 Issue 2 Pages 126-133

DOI https://doi.org/10.5795/jjscc.45.126

Details

Abstract

Objective: We studied the cytological features of LEGH and MDA.
:Study Design:: We retrieved 13 cases of 11 LEGH and 2 MDA cases of the uterine cervix. There were 26 cytologic smears from 13 patients available for this study. Cytological features were carefully observed under light microscopy.
Results: Abundant yellow mucin is frequently found in LEGH and MDA. 1) INCI (intranuclear cytoplasmic inclusion) was observed at 63.6%(7/11) in LEGH and it was not found in any MDA. 2) Neither cell atypia nor architectural distortion was observed in LEGH; 3) In MDA, 3-dimensional irregular cell clustering and prominent nucleoli were seen.
Conclusion: 1) INC' is a good parameter in diagnosing LEGH; 2) Cytological examination is a potent aid to differentiating LEGH from MDA.

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