Validity of cervical cytology and human papillomavirus (HPV) testing in high grade-squamous intraepithelial lesions

Abstract

We evaluated the feasibility of cervical cytology and human papillomavirus (HPV) testing, analyzing 67 patients cytologically diagnosed with at least mild dysplasia. Positive criteria of cytology, histology, and HPV tests were class HSIL or greater, CIN2 or more, and HPV index >1. The gold standard was punch biopsy histology. The sensitivity of cytology was 47.7%, 86.4% HPV testing and both 89.3%. The negative predictivity of cytology, was 67.6%, 87.0% HPV testing and both 83.3%. Cervical screening with both cytology and HPV testing effectively distinguishes the disease requiring treatment.