2016 Volume 37 Issue 4 Pages 414-418
Angelman syndrome （AS） was first described in three unrelated children as “Puppet” syndrome by Harry Angelman in 1965. The clinical features of AS are characterized by mental retardation, seizures, frequent paroxysms of laughter, ataxia, and characteristic faces （small head, large tongue and large lower jaw） due to a partial deficit on the paired chromosome 15 （q11-q13）. This chromosomal abnormality is located on the same genes that control the production of the GABA （gamma-amino butyric acid）-A receptors, which is a common channel for the action of many drugs used for general anesthesia. We report a case of general anesthesia of a 26-year-old man with Angelman syndrome for wisdom tooth extraction with a review of relevant literature. Anesthesia was induced with propofol and rocronium, and was maintained with oxygen and propofol. A total 5.0 ml of 2％ lidocaine with epinephrine was used for supplemental local anesthesia. There were no incidents during or after surgery.
