Journal of the Japanese Society for Disability and Oral Health
Online ISSN : 2188-9708
Print ISSN : 0913-1663
ISSN-L : 0913-1663
 
Clinical Use of Nitrous Oxide Inhalation Sedation in Patients with a History of Epilepsy
Tomoko KOMATSUSara MIYAZAKIRyota SHIGEFUJIKousuke YOKOYAMASachiko OHTAMasaichi LEEYoshinari MORIMOTO
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2021 Volume 42 Issue 2 Pages 153-159

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Abstract

Nitrous oxide inhalation sedation (IS) has been used for behavioral management of patients with epilepsy, although its use in patients with a history of epilepsy should be avoided. However, few clinical studies have been conducted on the relationship between treatment under IS and the inducement of epileptic seizures. Therefore, we investigated patients with epilepsy who had a history of epilepsy and were taking antiepileptic drugs, based on their medical records for the past 5 years, in order to determine whether they had seizures during dental treatment with or without IS. The subjects in this study were divided into the group in whom IS was used at the concentration of 30% nitrous oxide (IS use group), and the IS non-use group. The results of the study revealed the following.

1.There were 223 subjects with a mean age (SD) of 34.6 (13.0) years, including 81 subjects in the IS use group with a mean age (SD) of 35.2 (13.1) years, and 142 subjects in the IS non-use group with a mean age (SD) of 36.3 (14.0) years.

2.There were significantly more patients with intellectual disability in the IS non-use group compared to the IS use group, while there were significantly more patients with cerebral palsy in the IS use group compared to the IS non-use group.

3.The number of patients who had epileptic seizures during the treatment was 3 in the IS use group and 5 in the non-IS use group. Seven of these patients had epileptic seizures during the usual period, and there was no significant relationship between epileptic seizures during the treatment and IS use.

4.The inducement of epileptic seizures caused by IS was not significant.

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