Abstract
We retrospectively analyzed the oncologic outcomes of 45 patients with oropharyngeal squamous cell carcinoma (OPSCC) when treated primarily in our department between January 2005 and August 2012. Our treatment criteria included (1) transoral video-assisted surgery (TOVS) or concurrent chemoradiotherapy (CRT) for T1-T3 OPSCC patients, and (2) extended radical operation or CRT for selected T3 and T4 OPSCC patients. In the case of OPSCC patients in stage III or IV, cause-specific survival of TOVS is significantly better than that of CRT, and TOVS has a better locoregional control rate. In the case of OPSCC patients in stage III or IV, cause-specific survival of p16INK4a positive cohort is better than that of p16INK4a negative, although it is not statistically significant. Oncologic results of p16INK4a negative cohort when treated with TOVS are good, which suggests our TOVS approach may improve the outcome of p16INK4a negative patients.
