Abstract
We herein report the therapeutic results of laryngeal cancer cases that were treated in our department. The cases were 240 patients with newly diagnosed laryngeal squamous cell carcinoma treated radically in our department between 2001 and 2012. Their ages ranged from 37 to 89 years (median age: 69 years), and the male-to-female ratio was 219 : 21. A total of 88, 81, 49, and 22 patients were categorized as having T1, T2, T3, and T4a cancer, respectively. The patients received the following three initial treatments: laryngectomy, laryngeal preservative surgery, and radiation or concomitant intravenous chemoradiation ((C) RT). Of 169 patients with T1-2 carcinoma, 7, 5, and -157 patients received laryngectomy, laryngeal preservative surgery, and (C) RT, respectively. Among 71 patients with T3-4a carcinoma, 55, 3, and 13 patients received laryngectomy, laryngeal preservative surgery, and (C) RT, respectively. Thirty-nine patients died of the primary disease, and 36 patients died of other causes; it is noteworthy that 14 patients died of lung cancer. The 5-year overall survival rates and disease-specific survival rates based on the Kaplan-Meier method were 69.5% and 79.8%, respectively. Multivariate analysis showed that comorbidity (ACE-27 index), T and N classification, age, and alcohol drinking were significant factors for disease-specific survival, and comorbidity, T and N classification, and heavy smoker were significant factors for overall survival.
