Abstract
Invasive fungal sinusitis still has a poor prognosis, although removal of the lesion and infusion of antifungal drugs have been successfully applied to treat the disease in recent years. Here, we describe six cases of invasive fungal sinusitis that we experienced in the last 5 years. In case 1, MRI findings initially indicated a brain tumor spreading into the paranasal sinuses. Examination of a brain biopsy obtained by craniotomy resulted in the diagnosis of invasive fungal sinusitis, and skull base and reconstructive surgery were performed. Endoscopic sinus surgery was used to treat the other five cases. Two cases were diagnosed pathologically, resulting in a diagnosis of fungal invasion of the mucosa. In the other four cases, CT images indicated bone destruction and disease progression into the pterygopalatine fossa. Five patients survived but one patient died from underlying disease. This study demonstrates that this type of lesion can be removed by endoscopic sinus surgery and that appropriate infusion of Voriconazole is effective.
