A case of thyroid-like low-grade nasopharyngeal papillary adenocarcinoma of the posterior end of the nasal septum

Abstract

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma （TL-LGNPPA） is a rare low-grade tumor that predominantly occurs in the nasopharynx. The tumor shows papillary thyroid carcinoma-like histopathology, positive for thyroid transcription factor-1 （TTF-1）, but negative for thyroglobulin. We report a case of TL-LGNPPA at the posterior end of the nasal septum. A 30-year-old woman was found by chance to have a tumor at the posterior end of the nasal septum. We preoperatively diagnosed the tumor as an exophytic papilloma and endoscopically resected the tumor. The tumor was diagnosed by postoperative histopathology as TL-LGNPPA. More than one year after surgery, there is no evidence of recurrence or metastasis.