A case of HPV-associated squamous cell carcinoma of the lacrimal sac

Abstract

Tumors arising in the lacrimal drainage system, including the lacrimal sac, are rare, and more than half of epithelial tumors in the lacrimal sac are malignant. Lacrimal sac carcinoma can extend into the orbit, and balancing curative intent with functional preservation is crucial in treatment. Recently, reports of HPV-associated squamous cell carcinoma in the lacrimal ducts have been published. Based on previous reports, HPV-associated squamous cell carcinoma of the lacrimal sac is presumed to show a favorable response to treatment.
The present case was a man in his 60s who developed HPV-associated squamous cell carcinoma in the right lacrimal sac and underwent eye-sparing partial maxillectomy followed by postoperative radiation therapy. The postoperative course was favorable, and the patient was satisfied with the preservation of his eye. This case demonstrates a favorable treatment outcome for HPV-associated squamous cell carcinoma.